200 mg, 50 tablets
Item Number:
453
SAMe (S-adenosyl-methionine) is an amino acid derivative
normally synthesized in the body. SAMe is used by the body in three
important pathways:
- Methylation (contributing methyl groups to activate
certain molecules)
- The synthesis of polyamines (for cell growth, gene
expression, neuronal regeneration, etc.)
- Trans-sulfuration (synthesis of cysteine,
glutathione, and other sulfate chemicals)
In young, healthy people SAMe is well distributed
throughout the body as a result of its synthesis from methionine by
enzymes using ATP. However, in sickness and in age, system levels may
become depleted. Supplementation of the co-factors folate, TMG, vitamins
B6 and B12, together with SAMe appears to be an effective method to
overcome this deficiency. There is evidence that SAMe helps to
synthesize phosphatidylcholine, which keeps cell membranes fluid and is
used in the brain to make the neurotransmitter acetylcholine.
SAMe has multi-modal mechanisms of action that are
used throughout the body, and especially the liver. In order to perform
its detoxification role, the liver performs large numbers of complex
enzymatic reactions continually.
SAMe facilitates healthy methylation enzymatic
processes and boosts hepatic levels of the critical antioxidant,
glutathione. When liver function is compromised, glutathione is
depleted, which leads to free radical damage. In addition, SAMe acts as
a methyl donor in the synthesis and formation of phosphatidylcholine and
L-cysteine, both necessary for maintaining liver health.
